Semaglutide vs. Tirzepatide Prescriptions: Which Should You Ask For?

Semaglutide (Wegovy/Ozempic) and tirzepatide (Zepbound/Mounjaro) are both GLP-1 receptor agonists, but they work differently. Semaglutide targets only GLP-1 receptors.

What You Need to Know

Tirzepatide is a dual GIP/GLP-1 agonist, targeting two hormone pathways simultaneously. Clinical trial results: SURMOUNT trials showed tirzepatide achieving approximately 20–25% weight loss at maximum dose, compared to approximately 15–17% for semaglutide in STEP trials. Tirzepatide produces slightly more weight loss on average, but individual responses vary significantly. Side effect profiles are similar (nausea, GI symptoms during titration), though some patients tolerate one better than the other.

The Details

Pricing: compounded semaglutide is generally cheaper ($99–299/month) vs compounded tirzepatide ($133–400/month). Brand-name Zepbound through LillyDirect starts around $399/month vs oral Wegovy at $149/month for the starting dose. Format: semaglutide is available as both injectable and oral (Wegovy pill). Tirzepatide is injectable only. If needle phobia is a barrier, semaglutide is the only option with an oral format..

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